Clinatec endowment Fonds Clinatec

Fonds Clinatec is a research center in its own right. As such, it conducts its own research projects in-house. These projects receive support from the Clinatec endowment fund’s partners and donors.

BioPhotons / Covea Neurotec

The Covéa NeuroTec program is investigating the effects of photobiomodulation on neurodegeneration in Alzheimer’s disease through several research projects.

The BioPhotons project focuses on the analysis of light emitted by brain cells. This light varies according to the disease and could become an early marker.

In the first part of the study, the Fonds Clinatec team is carrying out in vitro tests to establish the characteristics of photons emitted by diseased cells.

The second phase—preclinical trials—will test the feasibility of biophoton measurement in a mouse model of Alzheimer’s disease.

Pr John Mitrofanis – Dr Jamie Hoh Kam

Amodalz / Covea Neurotec

The Covéa NeuroTec program is investigating the effects of photobiomodulation on neurodegeneration in Alzheimer’s disease through several research projects.

The first objective of the Amodalz project is to study the impact of near-infrared light on neuronal degeneration in pre-clinical murine and primate models of Alzheimer’s disease, with the aim of demonstrating its neuroprotective effect.

The project will also test photobiomodulation (PBM) treatment in relation to the body’s circadian rhythms so that it can be optimized for patients’ internal clocks.

Pr John Mitrofanis – Dr Audrey Valverde

Tiroc / Covea Neurotec

The Covéa NeuroTec program is investigating the effects of photobiomodulation on neurodegeneration in Alzheimer’s disease through several research projects.

The Tiroc project involves a clinical trial to study the impact of near-infrared light applied extra-cranially on the brain activity of young and elderly subjects.

During functional MRI sessions, each subject will be in a resting state, then perform motor and cognitive tasks. The results will be used to map the effect of photobiomodulation in the brain.

In a future clinical trial, this protocol will be applied to Alzheimer’s patients.

Pr John Mitrofanis – Dr Marjorie Dole

KLESIA SomniBrain

Sleep disorders are an unfortunate side effect of many neurological diseases. The objectives of the KLESIA SomniBrain project are to measure the impact of photobiomodulation (PBM) on sleep quality and study the technique’s preventive and curative effects in patients with Parkinson’s disease.

Pre-clinical cognitive and motor tests were carried out on Parkinsonian subjects after near-infrared illumination during sleep.

The test results can be used to monitor the evolution of the pathology and verify the impact of photobiomodulation.

Dr Brigitte Piallat – Pr John Mitrofanis – Magali Bartolmucci – Kevin Paul

AstroPark

The aim of the AstroPark project is to understand the mechanisms triggered by electrostimulation at the cellular level.

By providing answers to some fundamental questions, this research will help scientists improve how these techniques are used.

The mechanisms of electrostimulation are analyzed using an in vitro electrostimulation bench.

Pr Pierre Magistretti – Dr Arnaud Pautrat

DBS Sommeil

The DBS Sommeil project focuses on Parkinson’s disease, and more specifically on the regulation of sleep disorders using Deep Brain Stimulation (DBS).

Based on a defined pre-clinical model, different stimulation frequencies are tested to assess their impact on sleep and the possibilities for regulating it.

This approach could re-establish a normal sleep cycle in Parkinson’s patients, helping to combat the progression of the disease.

Dr Brigitte Piallat – Nathan Barbe

We need your help to get new treatments to patients faster

Your donations pay for the additional staff and other resources we need to accelerate our research. Contact the Clinatec endowment fund today. Our people will be happy to work with you to see how you can best help us: contact@fonds-clinatec.fr.